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Index > Protein center > Crem(Gene name) > Rat
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  • Crem (Gene name),
  • cAMP-responsive element modulator (Protein name ),  CREM_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Crem;
    Protein name:
    cAMP-responsive element modulator;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Binds DNA as a dimer (By similarity). Interacts with CDC34 (By similarity). Interacts with FHL5. Isoform delta forms a heterodimer with CREB3L4.
    Function:
    Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    357
    Sequence:
    50:
    MSKCGRKKYM | RTNVRQMTME | TVESQQDRSV | THSVAEHSSA | HMQTGQISVP | 
    100:
    TLAQVSVAGS | GTGRGSPAVT | LVQLPSGQTV | QVQGVIQTPH | PSVIQSPQIQ | 
    150:
    TVQVATIAET | DDSADSEVID | SHKRREILSR | RPSYRKILNE | LSSDVPGIPK | 
    200:
    IEEEKSEEEG | TPPNIATMAV | PTSIYQTSTG | QYIAIAQGGT | IQISNPGSDG | 
    250:
    VQGLQALTMT | NSGAPPPGAT | IVQYAAQSAD | GTQQFFVPGS | QVVVQDEETD | 
    300:
    LAPSHMAAAT | GDMPTYQIRA | PTTALPQGVV | MAASPGSLHS | PQQLAEEATR | 
    350:
    KRELRLMKNR | EAAKECRRRK | KEYVKCLESR | VAVLEVQNKK | LIEELETLKD | 
    357:
    ICSPKTD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat cAMP-responsive element modulator
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    ELISA Kit for Rat cAMP-responsive element modulator
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    ELISA Kit for Rat cAMP-responsive element modulator
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    CLIA Kit for Rat cAMP-responsive element modulator
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    U15147h
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    CLIA Kit for Rat cAMP-responsive element modulator
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    U15147r
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    Packing:
    96T
    CLIA Kit for Rat cAMP-responsive element modulator
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    U15147m
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    Packing:
    96T
    CLIA Kit for Rat cAMP-responsive element modulator
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    U15147b
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    CLIA Kit for Rat cAMP-responsive element modulator
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    U15147d
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    Polyclonal Antibody for Rat cAMP-responsive element modulator
    Polyclonal Antibody for Rat cAMP-responsive element modulator
    Polyclonal Antibody for Rat cAMP-responsive element modulator
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    P15147Rb-m
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    Polyclonal Antibody for Rat cAMP-responsive element modulator
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    Polyclonal Antibody for Rat cAMP-responsive element modulator
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    P15147Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat cAMP-responsive element modulator
    Monoclonal Antibody for Rat cAMP-responsive element modulator
    Monoclonal Antibody for Rat cAMP-responsive element modulator
    Monoclonal Antibody for Rat cAMP-responsive element modulator
    Monoclonal Antibody for Rat cAMP-responsive element modulator
    Protein for Rat cAMP-responsive element modulator
    Protein for Rat cAMP-responsive element modulator
    Protein for Rat cAMP-responsive element modulator
    Protein for Rat cAMP-responsive element modulator
    Protein for Rat cAMP-responsive element modulator

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      strain: Brown Norway.
      tissue: Testis.
    2. 2.
      "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes."
      Meyer T.E. , Habener J.F.
      Nucleic Acids Res.20:6106-6106(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-357 (ISOFORM TAU)
      tissue: Testis.
    3. 3.
      "Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis."
      Daniel P.B. , Rohrbach L. , Habener J.F.
      Endocrinology141:3923-3930(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-68 (ISOFORM 5);NUCLEOTIDE SEQUENCE [MRNA] OF 1-62 (ISOFORM 6);TISSUE SPECIFICITY
    4. 4.
      "Differential regulation of cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein and cAMP response element modulator messenger ribonucleic acid transcripts by follicle-stimulating hormone and androgen in the adult rat testis."
      West A.P. , Sharpe R.M. , Saunders P.T.
      Biol. Reprod.50:869-881(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;ALTERNATIVE SPLICING
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